![]() The expression of class II major histocompatibility complex antigens, such as HLA-DR, -DP and -DQ on keratinocytes did not change by CSA-treatment. Leu-6+ epithelial dendric cells (EDC) were found to significantly decrease in number in CSA-induced gingival overgrowth, while the ratio of HLA-DR+ EDC to Leu-6+ EDC did not change significantly. Statistically significant difference (P < 0.05) was found in PI GBI, PPD, and GO score between baseline, 3 months, and 6 months.Īll clinical parameters improved significantly after therapy without the need of further surgical treatment.įull-mouth disinfection might be a beneficial treatment concept in patients with drug-induced gingival overgrowth, thus decreasing the need for surgical therapy.Ĭyclosporin A (CSA)-induced gingival overgrowth was immunohistochemically compared with that phenytoin-induced and nonspecific inflammatory gingiva, and CSA concentration was determined for dental plaque. The data obtained for plaque index, bleeding on probing index, probing pocket depth, and gingival overgrowth scores were tabulated and compared statistically using the one sample unpaired t test. The patients were evaluated at 3 months and 6 months after therapy. Twenty patients between the ages of 20 and 50 years with drug-induced gingival overgrowth were treated using the full-mouth disinfection approach. This is followed by an additional subgingival irrigation (three times, repeated within 10 minutes) of all pockets with a 1% chlorhexidine gel. The recent concept mainly involves full-mouth scaling and root planing (the entire dentition in two visits within 24 hours, i.e., two consecutive days) followed by chair side mouth rinsing by the patient with a 0.2% chlorhexidine solution for 2 minutes and brushing the tongue of the patient with 1% chlorhexidine gel. These gingival overgrowths are usually treated by various modalities namely substitution of drugs, surgical, and non-surgical treatment. Multiple regression correlation, showed that GOI is more affected of PI (Beta=0,507) than Cs dose (Beta=0,197).Ĭonclusion: Local factors are significant in the development of gingival overgrowth (GO).ĭrug-induced gingival overgrowth is a common finding in the modern era. Significantly differ as compared to the first (100mg) and second (125mg) group no statistically significant differences were found among the other groups Statistically significant correlation were found between GOI andĬyclosporine dose (ρ =0,3 p<0,01) and also with PI (ρ= 0,6 p<0,01) and GI (ρ=0,3 p<0,01).Inter group comparison, showed the forth group (175mg) to It was registered a significant difference among distribution ofįrequency for gingival overgrowth between the examined groups (x2 test=12,672 p<0,01). Results: There were no statistical differences of PI at examined groups (p>0,05). The plaque index (PI), gingival index (GI), gingival overgrowth index (GOI), and cyclosporineĭose, were recorded for various groups and a prospective longitudinal follow - up was conducted. The cohort was divided into a four groups according to theĭaily dose of cyclosporine A(CsA) (100, 125, 150, 175 mg). Matherial and methods: 120 patients with renal transplants were included in this examination. The ethiology of DGO is multifactorial and probably the dental plaque has the major role in it.Īim: The aim of this study was to obtain the role of dental plaque in etiology of DGO. Drug-induced gingival overgrowth (DGO) is an adverse effect of certain medicines: immunosuppressive agents, antiepileptics, and calcium (Ca 2+) channelīlockers.
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